The binding of T-cell receptors to peptide molecules not normally present in the body can trigger an immune response. Predicting which peptide a T-cell receptor will bind to — a difficult feat — has now been achieved. See Letters p.89 & p.94
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References
Dash, P et al. Nature 547, 89–93 (2017).
Glanville, J. et al. Nature 547, 94–98 (2017).
Murphy, K., Travers, P., Walport, M. & Janeway, C. Janeway's Immunobiology 8th edn (Garland Science, 2012).
Sewell, A. K. Nature Rev. Immunol. 12, 669–677 (2012).
Friedensohn, S., Khan, T. A. & Reddy, S. T. Trends Biotechnol. 35, 203–214 (2017).
Dash, P. et al. J. Clin. Invest. 121, 288–295 (2011).
Han, A., Glanville, J., Hansmann, L. & Davis, M. M. Nature Biotechnol. 32, 684–692 (2014).
Altman, J. D. et al. Science 274, 94–96 (1996).
Garcia, K. C. & Adams, E. J. Cell 122, 333–336 (2005).
Emerson, R. O. et al. Nature Genet. 49, 659–665 (2017).
Attaf, M., Huseby, E. & Sewell, A. K. Cell Mol. Immunol. 12, 391–399 (2015).
Liu, X. S. & Mardis, E. R. Cell 168, 600–612 (2017).
Sun, Y. et al. Front. Immunol. 8, 430 (2017).
Pierce, B. G. et al. PLoS Comput. Biol. 10, e1003478 (2014).
Sadelain, M., Rivière, I. & Riddell, S. Nature 545, 423–431 (2017).
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Reddy, S. The patterns of T-cell target recognition. Nature 547, 36–38 (2017). https://doi.org/10.1038/nature23091
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DOI: https://doi.org/10.1038/nature23091
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