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The patterns of T-cell target recognition


The binding of T-cell receptors to peptide molecules not normally present in the body can trigger an immune response. Predicting which peptide a T-cell receptor will bind to — a difficult feat — has now been achieved. See Letters p.89 & p.94

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Figure 1: The patterns of T-cell receptor binding.


  1. 1.

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  1. 1

    Dash, P et al. Nature 547, 89–93 (2017).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Glanville, J. et al. Nature 547, 94–98 (2017).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Murphy, K., Travers, P., Walport, M. & Janeway, C. Janeway's Immunobiology 8th edn (Garland Science, 2012).

    Google Scholar 

  4. 4

    Sewell, A. K. Nature Rev. Immunol. 12, 669–677 (2012).

    CAS  Article  Google Scholar 

  5. 5

    Friedensohn, S., Khan, T. A. & Reddy, S. T. Trends Biotechnol. 35, 203–214 (2017).

    CAS  Article  Google Scholar 

  6. 6

    Dash, P. et al. J. Clin. Invest. 121, 288–295 (2011).

    CAS  Article  Google Scholar 

  7. 7

    Han, A., Glanville, J., Hansmann, L. & Davis, M. M. Nature Biotechnol. 32, 684–692 (2014).

    CAS  Article  Google Scholar 

  8. 8

    Altman, J. D. et al. Science 274, 94–96 (1996).

    ADS  CAS  Article  Google Scholar 

  9. 9

    Garcia, K. C. & Adams, E. J. Cell 122, 333–336 (2005).

    CAS  Article  Google Scholar 

  10. 10

    Emerson, R. O. et al. Nature Genet. 49, 659–665 (2017).

    CAS  Article  Google Scholar 

  11. 11

    Attaf, M., Huseby, E. & Sewell, A. K. Cell Mol. Immunol. 12, 391–399 (2015).

    CAS  Article  Google Scholar 

  12. 12

    Liu, X. S. & Mardis, E. R. Cell 168, 600–612 (2017).

    CAS  Article  Google Scholar 

  13. 13

    Sun, Y. et al. Front. Immunol. 8, 430 (2017).

    PubMed  PubMed Central  Google Scholar 

  14. 14

    Pierce, B. G. et al. PLoS Comput. Biol. 10, e1003478 (2014).

    Article  Google Scholar 

  15. 15

    Sadelain, M., Rivière, I. & Riddell, S. Nature 545, 423–431 (2017).

    ADS  CAS  Article  Google Scholar 

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Correspondence to Sai T. Reddy.

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Reddy, S. The patterns of T-cell target recognition. Nature 547, 36–38 (2017).

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