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Immunology: The patterns of T-cell target recognition

Nature volume 547, pages 3638 (06 July 2017) | Download Citation

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The binding of T-cell receptors to peptide molecules not normally present in the body can trigger an immune response. Predicting which peptide a T-cell receptor will bind to — a difficult feat — has now been achieved. See Letters p.89 & p.94

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References

  1. 1.

    et al. Nature 547, 89–93 (2017).

  2. 2.

    et al. Nature 547, 94–98 (2017).

  3. 3.

    , , & Janeway's Immunobiology 8th edn (Garland Science, 2012).

  4. 4.

    Nature Rev. Immunol. 12, 669–677 (2012).

  5. 5.

    , & Trends Biotechnol. 35, 203–214 (2017).

  6. 6.

    et al. J. Clin. Invest. 121, 288–295 (2011).

  7. 7.

    , , & Nature Biotechnol. 32, 684–692 (2014).

  8. 8.

    et al. Science 274, 94–96 (1996).

  9. 9.

    & Cell 122, 333–336 (2005).

  10. 10.

    et al. Nature Genet. 49, 659–665 (2017).

  11. 11.

    , & Cell Mol. Immunol. 12, 391–399 (2015).

  12. 12.

    & Cell 168, 600–612 (2017).

  13. 13.

    et al. Front. Immunol. 8, 430 (2017).

  14. 14.

    et al. PLoS Comput. Biol. 10, e1003478 (2014).

  15. 15.

    , & Nature 545, 423–431 (2017).

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  1. Sai T. Reddy is in the Department of Biosystems Science and Engineering, ETH Zürich, Basel 4058, Switzerland.

    • Sai T. Reddy

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Correspondence to Sai T. Reddy.

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https://doi.org/10.1038/nature23091

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