Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Synapses pruned in lupus

Lupus is an autoimmune disease that can cause brain dysfunction. Studies in mouse models of lupus find that interferon proteins can cause the brain's immune cells to trim the synaptic connections between neurons. See Letter p.539

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Synaptic pruning in autoimmunity.


  1. See all news & views


  1. Tsokos, G. C. N. Engl. J. Med. 365, 2110–2121 (2011).

    Article  CAS  Google Scholar 

  2. Bialas, A. R. et al. Nature 546, 539–543 (2017).

    ADS  Article  CAS  Google Scholar 

  3. Akwa, Y. et al. J. Immunol. 161, 5016–5026 (1998).

    PubMed  CAS  Google Scholar 

  4. Rodero, M. P. & Crow, Y. J. J. Exp. Med. 213, 2527–2538 (2016).

    Article  CAS  Google Scholar 

  5. Banchereau, R. et al. Cell 165, 551–565 (2016).

    Article  CAS  Google Scholar 

  6. Das, A. et al. Immunity 46, 106–119 (2017).

    Article  CAS  Google Scholar 

  7. Paolicelli, R. C. et al. Science 333, 1456–1458 (2011).

    ADS  Article  CAS  Google Scholar 

  8. Hong, S. et al. Science 352, 712–716 (2016).

    ADS  Article  CAS  Google Scholar 

  9. Kowal, C. et al. Proc. Natl Acad. Sci. USA 103, 19854–19859 (2006).

    ADS  Article  CAS  Google Scholar 

  10. Kavanagh, D. et al. Blood 128, 2824–2833 (2016).

    Article  CAS  Google Scholar 

  11. Rodero, M. P. et al. J. Exp. Med. 214, 1547–1555 (2017).

    Article  CAS  Google Scholar 

  12. Ejlerskov, P. et al. Cell 163, 324–339 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to David Hunt.

Additional information

UpdateThis News & Views article commented on a paper, entitled 'Microglia-dependent synapse loss in type I interferon-mediated lupus' (A. R. Bialas et al. Nature 546, 539–543; 2017), that has now been retracted.

Related links

Related links

Related links in Nature Research

Neuroinflammation: Surprises from the sanitary engineers

Microbiology: Gut microbes augment neurodegeneration

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

McGlasson, S., Hunt, D. Synapses pruned in lupus. Nature 546, 482–483 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing