Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neurodegenerative disease

RNA repeats put a freeze on cells

Nature volume 546, pages 215–216 (2017)Cite this article

Subjects

Droplet-like assemblies of RNA in cell nuclei are associated with certain neurodegenerative diseases. Experiments reveal that these assemblies become 'frozen' gels in cells, potentially explaining their toxicity. See Article p.243

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Foci formation.

Notes

  1. See all news & views

References

  1. Wojciechowska, M. & Krzyzosiak, W. J. Hum. Mol. Genet. 20, 3811–3821 (2011).

    Article  CAS  Google Scholar 

  2. Jain, A. & Vale, R. D. Nature 546, 243–247 (2017).

    Article  ADS  CAS  Google Scholar 

  3. Banani, S. F., Lee, H. O., Hyman, A. A. & Rosen, M. K. Nature Rev. Mol. Cell Biol. 18, 285–298 (2017).

    Article  CAS  Google Scholar 

  4. Brangwynne, C. P., Tompa, P. & Pappu, R. V. Nature Phys. 11, 899–904 (2015).

    Article  ADS  CAS  Google Scholar 

  5. Taylor, J. P., Brown, R. H. & Cleveland, D. W. Nature 539, 197–206 (2016).

    Article  ADS  Google Scholar 

  6. Liu, J. et al. Cell Chem. Biol. 24, 141–148 (2017).

    Article  Google Scholar 

  7. Urbanek, M. O., Jazurek, M., Switonski, P. M., Figura, G. & Krzyzosiak, W. J. Biochim. Biophys. Acta 1862, 1513–1520 (2016).

    Article  CAS  Google Scholar 

  8. Lee, Y.-B. et al. Cell Rep. 5, 1178–1186 (2013).

    Article  CAS  Google Scholar 

  9. Mackenzie, I. R. A. et al. Acta Neuropathol. 130, 845–861 (2015).

    Article  CAS  Google Scholar 

  10. Labbadia, J. & Morimoto, R. I. Trends Biochem. Sci. 38, 378–385 (2013).

    Article  CAS  Google Scholar 

  11. Clemson, C. M. et al. Mol. Cell 33, 717–726 (2009).

    Article  CAS  Google Scholar 

  12. Engreitz, J. M., Ollikainen, N. & Guttman, M. Nature Rev. Mol. Cell Biol. 17, 756–770 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Chemical and Biological Engineering, Princeton University, Princeton, 08540, New Jersey, USA

    David W. Sanders & Clifford P. Brangwynne

Authors
  1. David W. Sanders
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Clifford P. Brangwynne
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to David W. Sanders or Clifford P. Brangwynne.

Related audio

Related links

Related links

Related links in Nature Research

Neurodegeneration: Role of repeats in protein clearance

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sanders, D., Brangwynne, C. RNA repeats put a freeze on cells. Nature 546, 215–216 (2017). https://doi.org/10.1038/nature22503

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature22503

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing