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Neurodegenerative disease

RNA repeats put a freeze on cells

Droplet-like assemblies of RNA in cell nuclei are associated with certain neurodegenerative diseases. Experiments reveal that these assemblies become 'frozen' gels in cells, potentially explaining their toxicity. See Article p.243

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Figure 1: Foci formation.

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Correspondence to David W. Sanders or Clifford P. Brangwynne.

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Neurodegeneration: Role of repeats in protein clearance

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Sanders, D., Brangwynne, C. RNA repeats put a freeze on cells. Nature 546, 215–216 (2017). https://doi.org/10.1038/nature22503

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