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Neurodegenerative disease

RNA repeats put a freeze on cells

Droplet-like assemblies of RNA in cell nuclei are associated with certain neurodegenerative diseases. Experiments reveal that these assemblies become 'frozen' gels in cells, potentially explaining their toxicity. See Article p.243

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Figure 1: Foci formation.


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Correspondence to David W. Sanders or Clifford P. Brangwynne.

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Sanders, D., Brangwynne, C. RNA repeats put a freeze on cells. Nature 546, 215–216 (2017).

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