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Blood

Education for stem cells

Nature volume 545, pages 415–417 (2017)Cite this article

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Haematopoietic stem cells give rise to all lineages of blood cell, and their production in vitro has been a long-sought goal of stem-cell biology. Two groups now achieve this feat through different means. See Articles p.432 & p.439

The entire mammalian blood system can be restored from a single haematopoietic stem cell (HSC). These self-renewing cells reside in the bone marrow, where their proliferation and differentiation are tightly regulated to ensure a continued, lifetime supply of blood cells. The high regenerative capacity of HSCs makes them central to life-saving bone-marrow transplants, but also makes them prone to acquiring leukaemia-initiating genetic mutations. The ability to manufacture HSCs in the laboratory therefore holds enormous promise for cell therapy, drug screening and studies of leukaemia development. Two studies1,2 in this issue outline protocols to achieve just that.

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Figure 1: Production of haematopoietic stem cells in vitro.

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Authors and Affiliations

  1. Wellcome Trust and MRC Cambridge Stem Cell Institute,

    Carolina Guibentif & Berthold Göttgens

  2. Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK

    Carolina Guibentif & Berthold Göttgens

Authors
  1. Carolina Guibentif
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  2. Berthold Göttgens
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Corresponding authors

Correspondence to Carolina Guibentif or Berthold Göttgens.

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Stem cells: Reprogramming finds its niche

Developmental biology: It takes muscle to make blood cells

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Guibentif, C., Göttgens, B. Education for stem cells. Nature 545, 415–417 (2017). https://doi.org/10.1038/nature22496

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