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Tumours build their niche


It emerges that tumour cells can give rise to non-dividing cells that form part of the supporting microenvironment known as the niche. These niche cells secrete proteins that drive tumour growth and progression. See Letters p.355 & p.360

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Figure 1: Tumour cells and their niche.


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  1. Tammela, T. et al. Nature 545, 355–359 (2017).

    ADS  CAS  Article  Google Scholar 

  2. Lim, J. S. et al. Nature 545, 360–364 (2017).

    ADS  CAS  Article  Google Scholar 

  3. Clevers, H. & Nusse, R. Cell 149, 1192–1205 (2012).

    CAS  Article  Google Scholar 

  4. Kadowaki, T., Wilder, E., Klingensmith, J., Zachary, K. & Perrimon, N. Genes Dev. 10, 3116–3128 (1996).

    CAS  Article  Google Scholar 

  5. Sato, T. E. Nature 469, 415–418 (2011).

    ADS  CAS  Article  Google Scholar 

  6. Hayward, P., Kalmar, T. & Martinez Arias, A. Development 135, 411–424 (2008).

    CAS  Article  Google Scholar 

  7. Koch, U. & Radtke, F. Cell. Mol. Life Sci. 64, 2746–2762 (2007).

    CAS  Article  Google Scholar 

  8. Sutherland, K. D. et al. Cancer Cell 19, 754–764 (2011).

    CAS  Article  Google Scholar 

  9. Morimoto, M., Nishinakamura, R., Saga, Y. & Kopan, R. Development 139, 4365–4373 (2012).

    CAS  Article  Google Scholar 

  10. Noguchi, M., Sumiyama, K. & Morimoto, M. Cell Rep. 13, 2679–2686 (2015).

    CAS  Article  Google Scholar 

  11. Guha, A., Deshpande, A., Jain, A., Sebastiani, P. & Cardoso, W. V. Cell Rep. 19, 246–254 (2017).

    CAS  Article  Google Scholar 

  12. Pardo-Saganta, A. et al. Nature 523, 597–601 (2015).

    ADS  CAS  Article  Google Scholar 

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Correspondence to Meritxell Huch or Emma L. Rawlins.

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Huch, M., Rawlins, E. Tumours build their niche. Nature 545, 292–293 (2017).

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