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Tools to eliminate senescent cells

Ageing and many diseases are partly driven by the accumulation of damaged cells that no longer divide. It emerges that these senescent cells can be eradicated in mice using a drug that interferes with the activity of the protein FOXO4.

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Figure 1: Targeting a damaged cell population.


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  1. Muñoz-Espin, D. & Serrano, M. Nature Rev. Mol. Cell Biol. 15, 482–496 (2014).

    Article  Google Scholar 

  2. Zhu, Y. et al. Aging Cell 14, 644–658 (2015).

    Article  CAS  Google Scholar 

  3. Baker, D. J. et al. Nature 530, 184–189 (2016).

    Article  ADS  CAS  Google Scholar 

  4. Chang, J. et al. Nature Med. 22, 78–83 (2016).

    Article  ADS  CAS  Google Scholar 

  5. Yosef, R. et al. Nature Commun. 7, 11190 (2016).

    Article  ADS  CAS  Google Scholar 

  6. Schafer, M. J. et al. Nature Commun. 8, 14532 (2017).

    Article  ADS  CAS  Google Scholar 

  7. Baar, M. P. et al. Cell 169, 132–147 (2017).

    Article  CAS  Google Scholar 

  8. Neves, J., Demaria, M., Campisi, J. & Jasper, H. Dev. Cell 32, 9–18 (2015).

    Article  CAS  Google Scholar 

  9. Ovadya, Y. & Krizhanovsky, V. Biogerontology 15, 627–642 (2014).

    Article  CAS  Google Scholar 

  10. Greer, E. L. & Brunet, A. Oncogene 24, 7410–7425 (2005).

    Article  CAS  Google Scholar 

  11. Hosaka, T. et al. Proc. Natl Acad. Sci. USA 101, 2975–2980 (2004).

    Article  ADS  CAS  Google Scholar 

  12. Demaria, M. et al. Dev. Cell 31, 722–733 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Manuel Serrano.

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Serrano, M. Tools to eliminate senescent cells. Nature 545, 294–295 (2017).

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