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Structural biology

Signalling under the microscope

G-protein-coupled receptors are biological targets for drug discovery. Developments in cryo-electron microscopy have enabled the solution of the structure of a class B receptor in complex with its signalling protein. Two biologists and a microscopist explain the exciting implications of this work. See Article p.118

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Figure 1: Snapshot of a cellular signalling complex.


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Correspondence to Ching-Ju Tsai, Joerg Standfuss or Robert M. Glaeser.

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Tsai, CJ., Standfuss, J. & Glaeser, R. Signalling under the microscope. Nature 546, 36–37 (2017).

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