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Structural biology

Signalling under the microscope

G-protein-coupled receptors are biological targets for drug discovery. Developments in cryo-electron microscopy have enabled the solution of the structure of a class B receptor in complex with its signalling protein. Two biologists and a microscopist explain the exciting implications of this work. See Article p.118

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Figure 1: Snapshot of a cellular signalling complex.

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References

  1. Stevens, R. C. et al. Nature Rev. Drug Discov. 12, 25–34 (2013).

    Article  CAS  Google Scholar 

  2. Liang, Y.-L. et al. Nature 546, 118–123 (2017).

    Article  CAS  ADS  Google Scholar 

  3. Rasmussen, S. G. F. et al. Nature 477, 549–555 (2011).

    Article  CAS  ADS  Google Scholar 

  4. Hollenstein, K. et al. Trends Pharmacol. Sci. 35, 12–22 (2014).

    Article  CAS  Google Scholar 

  5. Lagerström, M. C. & Schiöth, H. B. Nature Rev. Drug Discov. 7, 339–357 (2008).

    Article  Google Scholar 

  6. Piscitelli, C. L., Kean, J., de Graaf, C. & Deupi, X. Mol. Pharmacol. 88, 536–551 (2015).

    Article  CAS  Google Scholar 

  7. Zernike, F. Science 121, 345–349 (1955).

    Article  CAS  ADS  Google Scholar 

  8. Danev, R., Buijsse, B., Khoshouei, M., Plitzko, J. M. & Baumeister, W. Proc. Natl Acad. Sci. USA 111, 15635–15640 (2014).

    Article  CAS  ADS  Google Scholar 

  9. Roth, M. et al. Nature 340, 659–662 (1989).

    Article  CAS  ADS  Google Scholar 

  10. Kim, J. et al. Nature 517, 396–400 (2015).

    Article  CAS  ADS  Google Scholar 

  11. Danev, R., Tegunov, D. & Baumeister, W. eLife 6, e23006 (2017).

    Article  Google Scholar 

  12. Khoshouei, M., Radjainia, M., Baumeister, W. & Danev, R. Preprint at bioRxiv http://dx.doi.org/10.1101/087841 (2016).

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Correspondence to Ching-Ju Tsai, Joerg Standfuss or Robert M. Glaeser.

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https://doi.org/10.1038/477540

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Tsai, CJ., Standfuss, J. & Glaeser, R. Signalling under the microscope. Nature 546, 36–37 (2017). https://doi.org/10.1038/nature22491

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