Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neurodegeneration

Role of repeats in protein clearance

Mutant proteins that contain stretches called polyQ repeats can misfold or form aggregates linked to neurodegeneration. It emerges that some polyQ-containing proteins regulate a process that degrades misfolded proteins. See Letter p.108

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Regulation of autophagy by proteins containing glutamine expansions.

Notes

  1. See all news & views

References

  1. Menzies, F. M. et al. Neuron 93, 1015–1034 (2017).

    Article  CAS  Google Scholar 

  2. Ashkenazi, A. et al. Nature 545, 108–111 (2017).

    Article  CAS  ADS  Google Scholar 

  3. Martin, D. D. O., Ladha, S., Ehrnhoefer, D. E. & Hayden, M. R. Trends Neurosci. 38, 26–35 (2015).

    Article  CAS  Google Scholar 

  4. Rui, Y.-N. et al. Nature Cell Biol. 17, 262–275 (2015).

    Article  CAS  Google Scholar 

  5. Ochaba, J. et al. Proc. Natl Acad. Sci. USA 111, 16889–16894 (2014).

    Article  CAS  ADS  Google Scholar 

  6. Wong, Y. C. & Holzbaur, E. L. F. J. Neurosci. 34, 1293–1305 (2014).

    Article  CAS  Google Scholar 

  7. Martin, D. D. O. et al. Hum. Mol. Genet. 23, 3166–3179 (2014).

    Article  CAS  Google Scholar 

  8. Ehrnhoefer, D. E. et al. Preprint at bioRxiv https://doi.org/10.1101/116178 (2017).

  9. https://clinicaltrials.gov/ct2/show/NCT02519036

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael R. Hayden.

Related links

Related links

Related links in Nature Research

Cell biology: Tagged tags engage disposal

Cell biology: Receptors for selective recycling

Neurodegeneration: An expansion in ALS genetics

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Martin, D., Hayden, M. Role of repeats in protein clearance. Nature 545, 33–34 (2017). https://doi.org/10.1038/nature22489

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature22489

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing