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Role of repeats in protein clearance

Mutant proteins that contain stretches called polyQ repeats can misfold or form aggregates linked to neurodegeneration. It emerges that some polyQ-containing proteins regulate a process that degrades misfolded proteins. See Letter p.108

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Figure 1: Regulation of autophagy by proteins containing glutamine expansions.


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Correspondence to Michael R. Hayden.

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Martin, D., Hayden, M. Role of repeats in protein clearance. Nature 545, 33–34 (2017).

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