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Neurodegeneration

Role of repeats in protein clearance

Nature volume 545, pages 33–34 (2017)Cite this article

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Mutant proteins that contain stretches called polyQ repeats can misfold or form aggregates linked to neurodegeneration. It emerges that some polyQ-containing proteins regulate a process that degrades misfolded proteins. See Letter p.108

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Figure 1: Regulation of autophagy by proteins containing glutamine expansions.

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Authors and Affiliations

  1. Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, V5H 4H4, British Columbia, Canada

    Dale D. O. Martin & Michael R. Hayden

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  1. Dale D. O. Martin
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  2. Michael R. Hayden
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Correspondence to Michael R. Hayden.

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Martin, D., Hayden, M. Role of repeats in protein clearance. Nature 545, 33–34 (2017). https://doi.org/10.1038/nature22489

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