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Molecular genetics

Chaperone protein gets personal

Nature volume 545, pages 36–37 (2017)Cite this article

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Two studies of the molecular chaperone protein HSP90 reveal how complex traits can be shaped by genetic and environmental context. This work highlights the challenges of personalized medicine.

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Figure 1: Heat-shock protein 90 (HSP90) alters the effects of genetic differences.

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References

  1. Neveling, K., Endt, D., Hoehn, H. & Schindler, D. Mutat. Res. 668, 73–91 (2009).

    Article  CAS  Google Scholar 

  2. Collins, F. S. & Varmus, H. N. Engl. J. Med. 372, 793–795 (2015).

    Article  CAS  Google Scholar 

  3. Karras, G. I. et al. Cell 168, 856–866 (2017).

    Article  CAS  Google Scholar 

  4. Hummel, B. et al. Nature Struct. Mol. Biol. 24, 234–242 (2017).

    Article  CAS  Google Scholar 

  5. Taipale, M., Jarosz, D. F. & Lindquist, S. Nature Rev. Mol. Cell. Biol. 11, 515–528 (2010).

    Article  CAS  Google Scholar 

  6. Rutherford, S. L. & Lindquist, S. Nature 396, 336–342 (1998).

    Article  ADS  CAS  Google Scholar 

  7. Jarosz, D. F., Taipale, M. & Lindquist, S. Annu. Rev. Genet. 44, 189–216 (2010).

    Article  CAS  Google Scholar 

  8. Siegal, M. L. & Leu, J.-Y. Annu. Rev. Ecol. Evol. Syst. 45, 496–517 (2014).

    Article  Google Scholar 

  9. Lander, E. S. et al. Nature 409, 860–921 (2001).

    Article  ADS  CAS  Google Scholar 

  10. Paaby, A. B. & Rockman, M. V. Nature Rev. Genet. 15, 247–258 (2014).

    Article  CAS  Google Scholar 

  11. Geiler-Samerotte, K. A., Zhu, Y. O., Goulet, B. E., Hall, D. W. & Siegal, M. L. PLoS Biol. 14, e2000465 (2016).

    Article  Google Scholar 

  12. Janssens, A. C. J. W. et al. Genet. Med. 8, 395–400 (2006).

    Article  MathSciNet  Google Scholar 

  13. Whitesell, L. et al. Proc. Natl Acad. Sci. USA 111, 18297–18302 (2014).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biology, Center for Genomics and Systems Biology, New York University, New York, 10003, New York, USA

    Mark L. Siegal

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  1. Mark L. Siegal
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Correspondence to Mark L. Siegal.

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Siegal, M. Chaperone protein gets personal. Nature 545, 36–37 (2017). https://doi.org/10.1038/nature22487

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