Extended Data Figure 4: ACSS2 enrichment co-occurs with histone acetylation at neuronal genes in differentiating CAD neurons. | Nature

Extended Data Figure 4: ACSS2 enrichment co-occurs with histone acetylation at neuronal genes in differentiating CAD neurons.

From: Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

Extended Data Figure 4

a, UCSC Genome Browser views of ChIP–seq tracks demonstrate that increases in H4K5, H4K12, and H3K9 acetylation co-occur with ACSS2 enrichment over the Idua (α-l-iduronidase) locus upon CAD neuron differentiation (chr5: 108,649,457–108,687,261). b, At the Slc19A1 (solute carrier family 19 member 1) gene, elevated histone H4K5, H4K12, and H3K9 acetylation levels correspond with increasing ACSS2 enrichment in differentiated CAD neurons (chr10: 76,761,141–77,170,455).

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