Extended Data Figure 10 : CCM formation is conferred to the offspring of resistant animals by fostering to Swiss Webster mothers.

From: Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Extended Data Figure 10

a, Schematic of the experimental design in which timed matings of resistant Krit1ECKO and resistant Ccm2ECKO mating pairs were used to generate E19.5 offspring delivered by natural birth and raised by the birth mother or C-section/fostered to conventional Swiss Webster foster mothers. b, c, Visual images of hindbrains from P10 resistant Krit1ECKO and Ccm2ECKO offspring following natural delivery and nursing by resistant mothers or after C-section/fostering to Swiss Webster mothers. n ≥ 6 per group.