Extended Data Figure 8 : Blockade of CCM formation by the TLR4 antagonist LPS-RS.

From: Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Extended Data Figure 8

a, Schematic of the experimental design in which Krit1ECKO littermates receive retro-orbital injections of the TLR4 antagonist LPS-RS. b, Visual (left) and microCT (right) images of hindbrains from vehicle or LPS-RS injected animals. c, d, Quantification of CCM lesion and brain volume in Krit1ECKO littermates treated with vehicle or LPS-RS. Error bars shown as s.e.m. and significance determined by unpaired, two-tailed Student’s t-test. **P < 0.01; n.s., indicates P > 0.05. All scale bars, 1 mm.