Extended Data Figure 6 : CCM formation can be stimulated by IL-1β or poly(I:C) treatment.

From: Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

Extended Data Figure 6

a, Schematic of the experimental design in which littermates receive a retro-orbital injection of the indicated cytokine or TLR ligand at P5 and P10 before tissue harvest and analysis at P17. bm, Visual images and volumetric quantification of CCM lesions in the hindbrains of P17 Ccm2ECKO littermates injected with the indicated cytokines, TLR ligands, or vehicle control are shown. Error bars shown as s.e.m. and significance determined by unpaired, two-tailed Student’s t-test. *P < 0.05; n.s., P > 0.05. Scale bars, 1 mm.