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Structural biology

A receptor that might block itself

The structure of the angiotensin II type 2 receptor reveals a potential mode of self-blocking action. This might explain its lack of signalling, and opens up avenues of investigation into its function and role in disease. See Article p.327

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Figure 1: An active-like state of the angiotensin II type 2 receptor (AT2R).


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Correspondence to Christopher G. Tate.

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Competing interests

C.G.T. is a consultant and shareholder in Heptares Therapeutics.

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Tate, C. A receptor that might block itself. Nature 544, 307–308 (2017).

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