The structure of the angiotensin II type 2 receptor reveals a potential mode of self-blocking action. This might explain its lack of signalling, and opens up avenues of investigation into its function and role in disease. See Article p.327
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C.G.T. is a consultant and shareholder in Heptares Therapeutics.
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Tate, C. A receptor that might block itself. Nature 544, 307–308 (2017). https://doi.org/10.1038/nature21907