Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell biology

Sort and destroy


Aggregates are aberrant, non-functional forms of protein that often build up in cells in response to stress. Organelles called mitochondria have now been found to be active players in the clearance of these protein aggregates. See Letter p.443

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Disposal of aggregating proteins by mitochondria.


  1. See all news & views


  1. Chacinska, A., Koehler, C. M., Milenkovic, D, Lithgow, T. & Pfanner, N. Cell 138, 628–644 (2009).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. Neupert, W. & Herrmann, J. M. Annu. Rev. Biochem. 76, 723–749 (2007).

    CAS  Article  PubMed  Google Scholar 

  3. Ruan, L. et al. Nature 543, 443–446 (2017).

    CAS  Article  ADS  PubMed  PubMed Central  Google Scholar 

  4. Balchin, D., Hayer-Hartl, M. & Hartl, F. U. Science 353, aac4354 (2016).

    Article  PubMed  Google Scholar 

  5. Ciryam, P., Kundra, R., Morimoto, R. I., Dobson, C. M. & Vendruscolo, M. Trends Pharmacol. Sci. 36, 72–77 (2015).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. Mogk, A., Kummer, E. & Bukau, B. Front. Mol. Biosci. 2, 22 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Sontag, E. M., Vonk, W. I. & Frydman, J. Curr. Opin. Cell Biol. 26, 139–146 (2014).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  8. Nyström, T. & Liu, B. FEMS Yeast Res. 14, 40–48 (2014).

    Article  PubMed  Google Scholar 

  9. Zhou, C. et al. Cell 159, 530–542 (2014).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  10. Sugiura, A., McLelland, G. L., Fon, E. A. & McBride, H. M. EMBO J. 33, 2142–2156 (2014).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  11. Wrobel, L. et al. Nature 524, 485–488 (2015).

    CAS  Article  ADS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Agnieszka Chacinska.

Related links

Related links

Related links in Nature Research

Cell biology: Surviving import failure

Molecular biology: It takes two to untangle

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Chacinska, A. Sort and destroy. Nature 543, 324–325 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing