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The chronicles of T-cell exhaustion


T cells of the immune system often fail to target cancer cells because they enter a dysfunctional state known as exhaustion. Molecular analysis of T-cell exhaustion provides insights into the clinical use of these cells.

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Figure 1: Temporary reversal of T-cell exhaustion.


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Correspondence to Robert A. Amezquita or Susan M. Kaech.

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Amezquita, R., Kaech, S. The chronicles of T-cell exhaustion. Nature 543, 190–191 (2017).

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