Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunology

T-cell tweaks to target tumours

Subjects

Immune cells known as T cells can destroy tumour cells, but their clinical use requires complex preparation and the cells can lose effectiveness over time. A new approach might improve the efficiency of T-cell therapy. See Letter p.113

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Making CAR T cells.

Notes

  1. See all news & views

References

  1. Maus, M. V. & June, C. H. Clin. Cancer Res. 22, 1875–1884 (2016).

    Article  CAS  Google Scholar 

  2. Eyquem, J. et al. Nature 543, 113–117 (2017).

    Article  CAS  ADS  Google Scholar 

  3. Qasim, W. et al. Sci. Transl. Med. http://dx.doi.org/10.1126/scitranslmed.aaj2013 (2017).

  4. Lombardo, A. et al. Nature Methods 8, 861–869 (2011).

    Article  CAS  Google Scholar 

  5. Wang, J. et al. Nucleic Acids Res. 44, e30 (2016).

    Article  Google Scholar 

  6. Sather, B. D. et al. Sci. Transl. Med. 7, 307ra156 (2015).

    Article  Google Scholar 

  7. Frigault, M. J. et al. Cancer Immunol. Res. 4, 356–367 (2015).

    Article  Google Scholar 

  8. Long, A. H. et al. Nature Med. 6, 581–590 (2015).

    Article  Google Scholar 

  9. Wherry, E. J. & Kurachi, M. Nature Rev. Immunol. 15, 486–499 (2015).

    Article  CAS  Google Scholar 

  10. Scholler, J. et al. Sci. Transl. Med. 4, 132ra53 (2012).

    Article  Google Scholar 

  11. Tsai, S. Q. & Joung, J. K. Nature Rev. Genet. 17, 300–312 (2016).

    Article  CAS  Google Scholar 

  12. Ren, J. et al. Clin. Cancer Res. http://dx.doi.org/10.1158/1078-0432.CCR-16-1300 (2017).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marcela V. Maus.

Related links

Related links

Related links in Nature Research

Immunology: The chronicles of T-cell exhaustion

Immunology: Cytotoxic T cells that escape exhaustion

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Maus, M. T-cell tweaks to target tumours. Nature 543, 48–49 (2017). https://doi.org/10.1038/nature21506

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature21506

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing