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A targeted treatment with off-target risks

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It emerges that blood-cancer-targeting drugs that block a tumour-survival pathway also activate a mutation-causing enzyme in mice and in human cells. This might have implications for the clinical use of these drugs. See Letter p.489

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Figure 1: Inhibition of a B-cell-receptor signalling pathway might increase the number of harmful mutations.

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  • 22 February 2017

    A new reference 10 has been added, in acknowledgement of the fact that this paper was the first to report that PI3Kδ suppresses expression of AID.


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Correspondence to David A. Fruman.

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Fruman, D., O'Brien, S. A targeted treatment with off-target risks. Nature 542, 424–425 (2017).

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