The enzyme S6K1 phosphorylates the enzyme glutamyl-prolyl tRNA synthetase to modulate metabolic activity and lifespan, revealing an atypical role for this synthetase as a target of a key metabolic signalling pathway. See Letter p.357
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Selman, C., Withers, D. An atypical switch for metabolism and ageing. Nature 542, 299–300 (2017). https://doi.org/10.1038/nature21500