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Physiology

An atypical switch for metabolism and ageing

Nature volume 542, pages 299–300 (2017)Cite this article

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The enzyme S6K1 phosphorylates the enzyme glutamyl-prolyl tRNA synthetase to modulate metabolic activity and lifespan, revealing an atypical role for this synthetase as a target of a key metabolic signalling pathway. See Letter p.357

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Figure 1: A phosphorylation switch alters lipid uptake and longevity in mice.

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Author information

Authors and Affiliations

  1. Colin Selman is at the Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK.,

    Colin Selman

  2. Dominic J. Withers is at the MRC London Institute of Medical Sciences, Imperial College London, London W12 0NN, UK.,

    Dominic J. Withers

Authors
  1. Colin Selman
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  2. Dominic J. Withers
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Correspondence to Dominic J. Withers.

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Selman, C., Withers, D. An atypical switch for metabolism and ageing. Nature 542, 299–300 (2017). https://doi.org/10.1038/nature21500

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