Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


An atypical switch for metabolism and ageing

The enzyme S6K1 phosphorylates the enzyme glutamyl-prolyl tRNA synthetase to modulate metabolic activity and lifespan, revealing an atypical role for this synthetase as a target of a key metabolic signalling pathway. See Letter p.357

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: A phosphorylation switch alters lipid uptake and longevity in mice.


  1. See all news & views


  1. Osborne, T. B., Mendel, L. B. & Ferry, E. L. Science 45, 294–295 (1917).

    Article  ADS  CAS  Google Scholar 

  2. Kennedy, B. K. & Lamming, D. W. Cell Metab. 23, 990–1003 (2016).

    Article  CAS  Google Scholar 

  3. Arif, A. et al. Nature 542, 357–361 (2017).

    Article  ADS  CAS  Google Scholar 

  4. Yao, P. & Fox, P. L. EMBO Mol. Med. 5, 332–343 (2013).

    Article  CAS  Google Scholar 

  5. Arif, A., Chatterjee, P., Moodt, R. A. & Fox, P. L. Mol. Cell. Biol. 32, 5046–5055 (2012).

    Article  CAS  Google Scholar 

  6. Selman, C. et al. Science 326, 140–144 (2009).

    Article  ADS  CAS  Google Scholar 

  7. Schaffer, J. E. & Lodish, H. F. Cell 79, 427–436 (1994).

    Article  CAS  Google Scholar 

  8. López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Cell 153, 1194–1217 (2013).

    Article  Google Scholar 

  9. Carnevalli, L. S. et al. Dev. Cell 18, 763–774 (2010).

    Article  CAS  Google Scholar 

  10. Kim, J. K. et al. J. Clin. Invest. 113, 756–763 (2004).

    Article  CAS  Google Scholar 

  11. Smith, M. A. et al. Cell Rep. 11, 335–343 (2015).

    Article  CAS  Google Scholar 

  12. Magnuson, B., Ekim, B. & Fingar, D. C. Biochem. J. 441, 1–21 (2012).

    Article  CAS  Google Scholar 

  13. Bitto, A. et al. eLife 5, e16351 (2016).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Dominic J. Withers.

Related links

Related links

Related links in Nature Research

Ageing: A healthy diet for stem cells

Ageing: Out with the old

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Selman, C., Withers, D. An atypical switch for metabolism and ageing. Nature 542, 299–300 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing