Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell biology

Organelle formation from scratch


Cellular organelles called peroxisomes aid metabolism, and defective peroxisome formation can cause disease. It emerges that peroxisomes can form de novo from the fusion of vesicles derived from two distinct organelle types. See Letter p.251

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Peroxisome formation.


  1. See all news & views


  1. Lazarow, P. B. & Fujiki, Y. Annu. Rev. Cell Biol. 1, 489–530 (1985).

    CAS  Article  Google Scholar 

  2. Agrawal, G. & Subramani, S. Biochim. Biophys. Acta 1863, 892–901 (2016).

    CAS  Article  Google Scholar 

  3. Sugiura, A., Mattie, S., Prudent, J. & McBride, H. M. Nature 542, 251–254 (2017).

    CAS  Article  ADS  Google Scholar 

  4. Goldfischer, S. et al. Science 182, 62–64 (1973).

    CAS  Article  ADS  Google Scholar 

  5. Klouwer, F. C. et al. Orphanet J. Rare Dis. 10, 151 (2015).

    Article  Google Scholar 

  6. Gould, S. J. & Valle, D. Trends Genet. 16, 340–345 (2000).

    CAS  Article  Google Scholar 

  7. Jones, J. M., Morrell, J. C. & Gould, S. J. J. Cell Biol. 164, 57–67 (2004).

    CAS  Article  Google Scholar 

  8. Fang, Y., Morrell, J. C., Jones, J. M. & Gould, S. J. J. Cell Biol. 164, 863–875 (2004).

    CAS  Article  Google Scholar 

  9. Matsuzaki, T. & Fujiki, Y. J. Cell Biol. 183, 1275–1286 (2008).

    CAS  Article  Google Scholar 

  10. Sugiura, A., McLelland, G.-L., Fon, E. A. & McBride, H. M. EMBO J. 33, 2142–2156 (2014).

    CAS  Article  Google Scholar 

  11. Yáñez-Mó, M. et al. J. Extracell. Vesicles 4, 27066 (2015).

    Article  Google Scholar 

  12. Gould, S. B., Garg, S. G. & Martin, W. F. Trends Microbiol. 24, 525–534 (2016).

    CAS  Article  Google Scholar 

  13. Schwechheimer, C. & Kuehn, M. J. Nature Rev. Microbiol. 13, 605–619 (2015).

    CAS  Article  Google Scholar 

  14. Lam, S. K., Yoda, N. & Schekman, R. Proc. Natl Acad. Sci. USA 107, 21523–21528 (2010).

    CAS  Article  ADS  Google Scholar 

  15. South, S. T. & Gould, S. J. J. Cell Biol. 144, 255–266 (1999).

    CAS  Article  Google Scholar 

  16. Hoepfner, D., Schildknegt, D., Braakman, I., Philippsen, P. & Tabak, H. F. Cell 122, 85–95 (2005).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Ewald H. Hettema or Stephen J. Gould.

Related links

Related links

Related links in Nature Research

Cell biology: The organelle replication connection

Cell biology: Sort of unexpected

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hettema, E., Gould, S. Organelle formation from scratch. Nature 542, 174–175 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing