Extended Data Figure 8 : LncRNA AP001057.1 is associated with classical monocytes and implicated in immune diseases.

From: An atlas of human long non-coding RNAs with accurate 5′ ends

Extended Data Figure 8

a, Genomic view of AP001057.1 (ENSG00000232124) in the ZENBU genome browser43. The strongest TSS of AP001057.1 overlaps with an enhancer DHS. The locus overlaps with fine-mapped SNPs associated with Crohn’s disease and GWAS SNPs associated with coeliac disease and inflammatory bowel disease. b, AP001057.1 is associated with classical monocytes (CL:0000860). c, AP001057.1 is significantly upregulated in monocytes upon stimulation with various immunogenic agents (FDR < 0.05 in edgeR58, highlighted in red and indicated with asterisks). Note: we performed differential expression analysis to identify lncRNAs that are dynamically regulated upon stimulation, infection or differentiation on the basis of 25 manually curated series of FANTOM5 samples (Supplementary Table 18 and Methods), and the results are available in Supplementary Table 19. Figures were captured (with slight modifications) from the online resource at http://fantom.gsc.riken.jp/cat/v1/#/genes/ENSG00000232124.1.