Inflammation, metaflammation and immunometabolic disorders


Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases.

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Figure 1: Immunometabolic impact on health.
Figure 2: Evolutionary conservation of immune and metabolic pathway crosstalk.
Figure 3: Convergence of key signalling molecules on both metabolic and inflammatory pathways and functional outcomes.


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I am grateful to all members of the Hotamisligil laboratory for helpful discussions, and especially G. Parlakgül for the initial preparation of figures, and K. Claiborn for discussions and invaluable editorial assistance. Work in the Hotamisligil laboratory is supported by grants from the National Institutes of Health (DK052539, HL125753, AI116901), the JDRF (2SRA-2016-147-Q-R), and sponsored research agreements from Union Chemique Belge and Servier.

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Correspondence to Gökhan S. Hotamisligil.

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Reviewer Information Nature thanks M. Febbraio and R. Kahn for their contribution to the peer review of this work.

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Hotamisligil, G. Inflammation, metaflammation and immunometabolic disorders. Nature 542, 177–185 (2017).

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