When some cancer cells delete a tumour-suppressor gene, they also delete nearby genes. It emerges that one of these latter genes has a key metabolic role, revealing a therapeutic opportunity that might be relevant for many tumours. See Letter p.119
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Muller, F. L., Aquilanti, E. A. & DePinho, R. A. Trends Cancer 1, 161–173 (2015).
Dey, P. et al. Nature 542, 119–123 (2017).
Lord, C. J. & Ashworth, A. Nature 481, 287–294 (2012).
Farmer, H. et al. Nature 434, 917–921 (2005).
Von Hoff, D. D. et al. N. Engl. J. Med. 369, 1691–1703 (2013).
Conroy, T. et al. N. Engl. J. Med. 364, 1817–1825 (2011).
Vander Heiden, M. G. Nature Rev. Drug Discov. 10, 671–684 (2011).
Ying, H. et al. Cell 149, 656–670 (2012).
Biankin, A. V. et al. Nature 491, 399–405 (2012).
Jiang, P., Du, W., Mancuso, A., Wellen, K. E. & Yang, X. Nature 493, 689–693 (2013).
Chio, I. I. C. et al. Cell 166, 963–976 (2016).
DeNicola, G. M. et al. Nature 475, 106–109 (2012).
Author information
Authors and Affiliations
Corresponding authors
Related links
Rights and permissions
About this article
Cite this article
Biffi, G., Tuveson, D. Double trouble for tumours. Nature 542, 34–35 (2017). https://doi.org/10.1038/nature21117
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature21117
This article is cited by
-
Caspase-2: an orphan enzyme out of the shadows
Oncogene (2017)
