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Stem cells

Valine starvation leads to a hungry niche

The haematopoietic stem cells that rejuvenate blood depend on a dietary source of the amino acid valine — a finding that has been exploited to reduce the toxicity of bone-marrow transplantation in mice.

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Figure 1: Reducing toxicity in bone-marrow transplantation.

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References

  1. Taya, Y. et al. Science 354, 1152–1155 (2016).

    Article  ADS  CAS  Google Scholar 

  2. Yu, V. W. C. & Scadden, D. T. Curr. Top. Dev. Biol. 118, 21–44 (2016).

    Article  CAS  Google Scholar 

  3. Kornberg, A. J. Biol. Chem. 164, 203–212 (1946).

    CAS  PubMed  Google Scholar 

  4. Mendelson, A. & Frenette, P. S. Nature Med. 20, 833–846 (2014).

    Article  CAS  Google Scholar 

  5. Signer, R. A. J., Magee, J. A., Salic, A. & Morrison, S. J. Nature 509, 49–54 (2014).

    Article  ADS  CAS  Google Scholar 

  6. Czechowicz, A., Kraft, D., Weissman, I. L. & Bhattacharya, D. Science 318, 1296–1299 (2007).

    Article  ADS  CAS  Google Scholar 

  7. Palchaudhuri, R. et al. Nature Biotechnol. 34, 738–745 (2016).

    Article  CAS  Google Scholar 

  8. McIntosh, B. E. et al. Stem Cell Rep. 4, 171–180 (2015).

    Article  CAS  Google Scholar 

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Correspondence to George Q. Daley.

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Rowe, R., Daley, G. Valine starvation leads to a hungry niche. Nature 541, 166–167 (2017). https://doi.org/10.1038/nature21106

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