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Stem cells

Valine starvation leads to a hungry niche

The haematopoietic stem cells that rejuvenate blood depend on a dietary source of the amino acid valine — a finding that has been exploited to reduce the toxicity of bone-marrow transplantation in mice.

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Figure 1: Reducing toxicity in bone-marrow transplantation.


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Correspondence to George Q. Daley.

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Rowe, R., Daley, G. Valine starvation leads to a hungry niche. Nature 541, 166–167 (2017).

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