Two studies in mice identify mechanisms by which tumour cells disseminate in very early breast cancer. Both show that these cells colonize distant tissues more efficiently than their later counterparts. See Article p.552 & Letter p.588
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Involvement of immune system and Epithelial–Mesenchymal-Transition in increased invasiveness of clustered circulatory tumor cells in breast cancer
BMC Medical Genomics Open Access 20 November 2021
-
The lingering mysteries of metastatic recurrence in breast cancer
British Journal of Cancer Open Access 26 November 2020
-
Interconnectivity between molecular subtypes and tumor stage in colorectal cancer
BMC Cancer Open Access 04 September 2020
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Cancer Moonshot Blue Ribbon Panel Report 2016 (National Cancer Advisory Board, 2016); available at go.nature.com/2gjcaa5
Schmidt-Kittler, O. et al. Proc. Natl Acad. Sci. USA 100, 7737–7742 (2003).
Braun, S. et al. N. Engl. J. Med. 353, 793–802 (2005).
Hüsemann, Y. et al. Cancer Cell 13, 58–68 (2008).
Klein, C. A. Nature Rev. Cancer 9, 302–312 (2009).
Eyles, J. et al. J. Clin. Invest. 120, 2030–2039 (2010).
Sänger, N. et al. Int. J. Cancer 129, 2522–2526 (2011).
Rhim, A. D. et al. Cell 148, 349–361 (2012).
Gruber, I. V. et al. Anticancer Res. 36, 2345–2351 (2016).
Hosseini, H. et al. Nature 540, 552–558 (2016).
Harper, K. L. et al. Nature 540, 588–592 (2016).
Narod, S. A., Iqbal, J., Giannakeas, V., Sopik, V. & Sun, P. JAMA Oncol. 1, 888–896 (2015).
Aguirre-Ghiso, J. A., Liu, D., Mignatti, A., Kovalski, K. & Ossowski, L. Mol. Biol. Cell 12, 863–879 (2001).
Ghajar, C. M. Nature Rev. Cancer 15, 238–247 (2015).
Author information
Authors and Affiliations
Corresponding authors
Related links
Rights and permissions
About this article
Cite this article
Ghajar, C., Bissell, M. Pathways of parallel progression. Nature 540, 528–529 (2016). https://doi.org/10.1038/nature21104
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature21104
This article is cited by
-
Involvement of immune system and Epithelial–Mesenchymal-Transition in increased invasiveness of clustered circulatory tumor cells in breast cancer
BMC Medical Genomics (2021)
-
The lingering mysteries of metastatic recurrence in breast cancer
British Journal of Cancer (2021)
-
Interconnectivity between molecular subtypes and tumor stage in colorectal cancer
BMC Cancer (2020)
-
The Tumor Microenvironment of Pediatric Sarcoma: Mesenchymal Mechanisms Regulating Cell Migration and Metastasis
Current Oncology Reports (2019)
-
Targeting Gas6/TAM in cancer cells and tumor microenvironment
Molecular Cancer (2018)