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Systems biology

Molecular memoirs of a cellular family

A system that introduces random modifications to barcode sequences embedded in cells' DNA allows lineage relationships between cells to be discerned, while preserving the cells' spatial relationships. See Letter p.107

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Figure 1: Lineage tracing finds its place.


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  1. Frieda, K. L. et al. Nature 541, 107–111 (2016).

    ADS  Article  Google Scholar 

  2. Sulston, J. E., Schierenberg, E., White, J. G. & Thomson, J. N. Dev. Biol. 100, 64–119 (1983).

    CAS  Article  Google Scholar 

  3. Sulston, J. E. & Horvitz, H. R. Dev. Biol. 56, 110–156 (1977).

    CAS  Article  Google Scholar 

  4. Raj, A., van den Bogaard, P., Rifkin, S. A., van Oudenaarden, A. & Tyagi, S. Nature Methods 5, 877–879 (2008).

    CAS  Article  Google Scholar 

  5. Lubeck, E., Coskun, A. F., Zhiyentayev, T., Ahmad, M. & Cai, L. Nature Methods 11, 360–361 (2014).

    CAS  Article  Google Scholar 

  6. Levesque, M. J. & Raj, A. Nature Methods 10, 246–248 (2013).

    CAS  Article  Google Scholar 

  7. Levsky, J. M., Shenoy, S. M., Pezo, R. C. & Singer, R. H. Science 297, 836–840 (2002).

    ADS  CAS  Article  Google Scholar 

  8. Lubeck, E. & Cai, L. Nature Methods 9, 743–748 (2012).

    CAS  Article  Google Scholar 

  9. Chen, K. H., Boettiger, A. N., Moffitt, J. R., Wang, S. & Zhuang, X. Science 348, aaa6090 (2015).

    Article  Google Scholar 

  10. McKenna, A. et al. Science 353, aaf7907 (2016).

    Article  Google Scholar 

  11. Crosetto, N., Bienko, M. & van Oudenaarden, A. Nature Rev. Genet. 16, 57–66 (2015).

    CAS  Article  Google Scholar 

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Correspondence to Lauren E. Beck or Arjun Raj.

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Beck, L., Raj, A. Molecular memoirs of a cellular family. Nature 541, 38–39 (2017).

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