Extended Data Figure 4 : EM density of the CLC-K channel.

From: Structure of a CLC chloride ion channel by cryo-electron microscopy

Extended Data Figure 4

EM density segments (mesh) of the class-1 CLC-K reconstruction are superimposed with the model in a ribbon representation. Numbers indicate amino acid positions of segments. The density map was sharpened with a B-factor of −100 Å2 and low-pass filtered at 3.7 Å. CTD, cytosolic domain. VL, variable domain of the IgG light chain. VH, variable domain of the IgG heavy chain. Note that a model for the distal half of the Fab fragment was not built because of poor density features in this region caused by its high flexibility (see also Extended Data Fig. 2b).