Extended Data Figure 10 : Microbiota control of post-dieting metabolic complications through intestinal flavonoids.

From: Persistent microbiome alterations modulate the rate of post-dieting weight regain

Extended Data Figure 10

a, Schematic showing sampling times in obesity/recovery cycle experiment. b, Dietary flavonoids in NC and HFD. ce, Abundance of flavanone 4-reductase (c), chalcone synthase (d), and eriodictyol (e) over time in the faeces of mice undergoing weight cycling normalized to controls. f, Quantification of flavanone 4-reductase levels in faecal DNA relative to host DNA in weight-cycling mice at the end of the weight loss period, with or without antibiotic treatment during weight loss. g, Schematic of sampling time upon weight regain. h, i, Abundance of apigenin (h) and naringenin (i) in the faeces of mice undergoing post-dieting weight regain and controls. jm, Flavonoid levels (j), PCoA of faecal microbiota (k), net weight gain induced by 8 weeks of HFD (l), and weight regain quantification by AUC (m) of weight-cycling mice supplemented with apigenin and naringenin during the weight regain. Data are from one (ak) or two (l, m) experiments. Shown are mean ± s.e.m. *P < 0.05, **P < 0.01 by ANOVA (c, e, l) or Mann–Whitney U-test (h, m). See Supplementary Tables 5 and 6 for exact n and P values.