Extended Data Figure 9 : Persistent metabolomic changes after dieting.

From: Persistent microbiome alterations modulate the rate of post-dieting weight regain

Extended Data Figure 9

ah, Examples of metabolites whose abundance is reversibly decreased (a, b), reversibly increased (c, d), persistently decreased (e, f), or persistently increased (g, h) during obesity and dieting. i, Schematic of flavonoid biosynthetic pathways leading to the production and conversion of naringenin. KEGG IDs of key enzymes are indicated. Genes found in our metagenomic dataset are indicated in green. Data are from one experiment. Shown are mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by ANOVA. See Supplementary Tables 5 and 6 for exact n and P values.