Extended Data Figure 7 : The post-dieting microbiota drives enhanced recurrent obesity.

From: Persistent microbiome alterations modulate the rate of post-dieting weight regain

Extended Data Figure 7

a, b, PCoA (a) and alpha diversity (b) of faecal microbiota after dieting (nadir time point at week 8) from mice with or without antibiotic treatment during weight loss. c, Net weight gain induced by 8 weeks of HFD in weight-cycling mice or continuous HFD control with or without antibiotic treatment between weeks 4 and 8. d, e, Glucose levels after oral glucose tolerance test (d) and glucose level quantification after glucose tolerance test (e) during weight regain in mice with or without antibiotic treatment during weight loss (n = 4–10). fh, PCoA of faecal microbiota from formerly obese mice and controls at the time of dieting-induced weight normalization (f), 15 weeks after weight normalization (g), and 21 weeks after weight normalization (h). ik, Correlation analysis (i) and examples (j, k) of microbial taxa undergoing gradual normalization in abundance over a period of 21 weeks after weight normalization. l, Quantification of secondary weight gain after microbiota normalization. Experiments were repeated twice. Data are mean ± s.e.m. **P < 0.01, ***P < 0.001 by ANOVA. See Supplementary Tables 5 and 6 for exact n and P values.