Extended Data Figure 6 : Persistent metagenomic changes after dieting.

From: Persistent microbiome alterations modulate the rate of post-dieting weight regain

Extended Data Figure 6

a, Heatmap of normalized gene abundance in the microbiota of mice before, during, and after obesity. b, c, Examples of genes whose abundance does not recover after dieting. d, PCA of bacterial KEGG modules over time in weight-cycling mice and controls. ej, Examples of KEGG pathways whose abundance is reversibly decreased (e, f), reversibly increased (g, h), or persistently decreased (i, j) during obesity and dieting. Data are from one experiment. Data are mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by ANOVA. See Supplementary Tables 5 and 6 for exact n and P values.