Extended Data Figure 5 : Persistent microbiome changes after dieting.

From: Persistent microbiome alterations modulate the rate of post-dieting weight regain

Extended Data Figure 5

a, Quantification of UniFrac distances of weight-cycling mice from NC controls at the indicated time points. Plots correspond to the PCoA analyses in Fig. 2b–f. bd, PCoA analyses and distance quantification (insets) of V3/V4-targeted 16S sequencing of mice before (b), during (c), and after (d) diet-induced obesity and subsequent weight loss. ei, Examples of OTUs whose abundance does (e, f) or does not (gi) recover after dieting. jm, PCoA analyses (j, k), UniFrac distance (l) and alpha diversity (m) at the nadir time point of post-dieting mice that had received celastrol to accelerate weight loss. Experiments were repeated twice. Data are mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by ANOVA. See Supplementary Tables 5 and 6 for exact n and P values.