Extended Data Figure 10 : PGR, HER2 signalling and dissemination in breast cancer patients.

From: Early dissemination seeds metastasis in breast cancer

Extended Data Figure 10

a, Double staining of a HER2high/PGRhigh human breast cancer sample (PGR, brown, nucleus; HER2, red/pink, membrane). Cells with varying expression levels of HER2 and PGR, as well as negative, single- or double-positive cells can be seen. Scale bar, 100 μm. Arrows indicate, double-positive (DP), double-negative (DN) and single-positive (SP) cells. b, Lack of PGR expression in high-density areas of HER2high/PGRhigh-classified tumour samples (see Fig. 5c) is directly linked to high miR-9-5p and miR-30a-5p expression. Data are mean ± s.d.