Extended Data Figure 9 : Phylogenetic analysis of metastasis (late divergence).

From: Early dissemination seeds metastasis in breast cancer

Extended Data Figure 9

a, Phylogenetic trees of the top 14 out of 28 primary tumour and matched metastasis samples listed according to latest time point of dissemination. For the first three mice the phylogenetic paths (mid), prototype aberrations (top right) and segmented array CGH profiles (bottom right) are also shown next to the phylogenetic tree (left). See Methods and Extended Data Figs 7, 8. b, Summary table of all phylogenetic analyses indicates the position of the corresponding mouse phylogenetic tree in Extended Data Figs 8 and 9 (EDF8 and EDF9) for each primary tumour–metastasis pair. The two bottom rows indicate the rank and the corresponding relative time point of dissemination as measured by the proportion of aberrations shared between primary tumour and metastasis (PT–M pcab; see Extended Data Fig. 7 and Fig. 4j). Note that only metastases ranked on position 36–44 diverged late. The phylogenetic tree and phylogenetic paths for mouse 3769 are displayed in Fig. 4h, i. In the pos-EDF8 and pos-EDF9 rows the darker colours are samples of which all data, including phylogenetic paths, prototype aberrations, segmented array CGH profiles and phylogenetic trees are shown. Faint colours cells in pos-EDF8 and pos-EDF9 are samples where only phylogenetic trees are shown.