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Cardiovascular disease

A turbulent path to plaque formation

Plaque deposits often occur in curved arterial regions with turbulent blood flow. Endothelial cells have been found to respond to blood flow through a previously unidentified signalling pathway that affects plaque build-up. See Letter p.579

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Figure 1: Endothelial-cell signalling can affect plaque formation.

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Correspondence to Ellie Tzima.

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Mehta, V., Tzima, E. A turbulent path to plaque formation. Nature 540, 531–532 (2016). https://doi.org/10.1038/nature20489

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