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Pharmacology

Inside-out receptor inhibition

Nature volume 540, pages 344–345 (2016)Cite this article

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Structures of two chemokine receptor proteins in complex with small molecules reveal a previously unknown binding pocket that could be a drug target for treating a range of diseases involving this receptor family. See Letters p.458 & p.462

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Figure 1: Visualizing allosteric inhibition.

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Authors and Affiliations

  1. Thomas P. Sakmar and Thomas Huber are in the Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, New York 10065, USA.,

    Thomas P. Sakmar & Thomas Huber

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  1. Thomas P. Sakmar
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  2. Thomas Huber
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Correspondence to Thomas P. Sakmar or Thomas Huber.

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Sakmar, T., Huber, T. Inside-out receptor inhibition. Nature 540, 344–345 (2016). https://doi.org/10.1038/nature20486

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