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Stem cells

Cause and consequence in aged-muscle decline

Nature volume 540, pages 349350 (15 December 2016) | Download Citation

Activation of aged muscle stem cells induces changes in DNA packaging that lead to expression of the gene Hoxa9. This reactivates embryonic signalling pathways, restricting the cells' ability to repair injured muscle. See Letter p.428

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Author information

Affiliations

  1. Susan Eliazer and Andrew S. Brack are in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and the Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California 94143, USA.

    • Susan Eliazer
    •  & Andrew S. Brack

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Corresponding author

Correspondence to Andrew S. Brack.

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DOI

https://doi.org/10.1038/nature20485

Further reading

  • CORR Insights®

    • Thomas Parker Vail

    Clinical Orthopaedics and Related Research (2018)

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