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Stem cells

Aspiring to naivety

Human stem cells that can give rise to every cell type in the body are major players in biomedical research. A molecular analysis of human embryos might help to make these cultured cells more authentic imitations of their in vivo counterparts.

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Figure 1: Molecular characterization of naive human stem cells.


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  1. De Los Angeles, A. et al. Nature 525, 469–478 (2015).

    Article  ADS  CAS  Google Scholar 

  2. Theunissen, T. W. et al. Cell Stem Cell 19, 502–515 (2016).

    Article  CAS  Google Scholar 

  3. Gafni, O. et al. Nature 504, 282–286 (2013).

    Article  ADS  CAS  Google Scholar 

  4. Chan, Y.-S. et al. Cell Stem Cell 13, 663–675 (2013).

    Article  CAS  Google Scholar 

  5. Theunissen, T. W. et al. Cell Stem Cell 15, 471–487 (2014).

    Article  CAS  Google Scholar 

  6. Takashima, Y. et al. Cell 158, 1254–1269 (2014).

    Article  CAS  Google Scholar 

  7. Huang, K., Maruyama, T. & Fan, G. Cell Stem Cell 15, 410–415 (2014).

    Article  CAS  Google Scholar 

  8. Smith, Z. D. et al. Nature 511, 611–615 (2014).

    Article  ADS  CAS  Google Scholar 

  9. Rugg-Gunn, P. J., Ferguson-Smith, A. C. & Pedersen, R. A. Nature Genet. 37, 585–587 (2005).

    Article  CAS  Google Scholar 

  10. Pastor, W. A. et al. Cell Stem Cell 18, 323–329 (2016).

    Article  CAS  Google Scholar 

  11. Petropoulos, S. et al. Cell 165, 1012–1026 (2016).

    Article  CAS  Google Scholar 

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Correspondence to Nissim Benvenisty.

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Sagi, I., Benvenisty, N. Aspiring to naivety. Nature 540, 211–212 (2016).

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