Sleep in mammals consists of non-rapid-eye-movement and rapid-eye-movement sleep. A large genetic screen reveals that these two sleep states are altered in mice by mutations dubbed Sleepy and Dreamless. See Article p.378
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Dijk, DJ., Winsky-Sommerer, R. Sleepy and dreamless mutant mice. Nature 539, 364–365 (2016). https://doi.org/10.1038/nature20471