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Molecular biology

Mature proteins braced by a chaperone

Hsp70 chaperone molecules help other proteins to fold, and were thought to bind mainly to unfolded proteins. Single-molecule experiments now suggest that Hsp70s can also stabilize almost fully folded proteins. See Letter p.448

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Figure 1: Different roles of Hsp70s in protein folding.

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Correspondence to Qinglian Liu or Elizabeth A. Craig.

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Liu, Q., Craig, E. Mature proteins braced by a chaperone. Nature 539, 361–362 (2016). https://doi.org/10.1038/nature20470

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