Extended Data Figure 8: Summary of eye colour and transgene of the pups derived from in-vitro-generated oocytes. | Nature

Extended Data Figure 8: Summary of eye colour and transgene of the pups derived from in-vitro-generated oocytes.

From: Reconstitution in vitro of the entire cycle of the mouse female germ line

Extended Data Figure 8

ac, A compiled list of eye colour and transgene of the pups derived from in-vitro-generated oocytes from BVSCH14 ESCs (a), MEF-derived iPSCs (MEF4FRC9 and MEF4FC14) (b), and TTF-derived iPSCs (TTF4FC6 and TTF4FRC3) (c). 3* and 5* pups from TTF4FC6 had albino eyes. This is because MEF-iPSCs and TTF-iPSCs (129X1/svj (chinchilla) × C57BL/6) used in this study have Cc or Ccch genotype that effects eye pigmentation (see also Method). As ICR strain has cc genotype, half of the offspring would have albino eyes. Note that these pups had BV and the retroviral transgenes. d, Fertility of adult mice derived from in-vitro-generated oocytes from iPSCs. Both a female (left) and a male (middle) from TTF-derived iPSCs were fertile. The table (right) shows the number of pups in a litter.

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