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Drug discovery

Chemical diversity targets malaria

A molecule selected from a library of compounds that have structures similar to natural products targets several stages of the malarial parasite's life cycle, offering single-dose treatment of the disease in mouse models. See Article p.344

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Figure 1: A compound that targets all parasite stages of malarial infection.

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References

  1. WHO. World Malaria Report 2015 www.who.int/malaria/publications/world-malaria-report-2015/report/en (2015).

  2. Kato, N. et al. Nature 538, 344–349 (2016).

    Article  CAS  ADS  Google Scholar 

  3. Ashley, E. A. et al. N. Engl. J. Med. 371, 411–423 (2014).

    Article  Google Scholar 

  4. Leang, R. et al. Antimicrob. Ag. Chemother. 59, 4719–4726 (2015).

    Article  CAS  Google Scholar 

  5. Lowe, J. T. et al. J. Org. Chem. 77, 7187–7211 (2012).

    Article  CAS  Google Scholar 

  6. Wells, T. N. C., Hooft van Huijsduijnen, R. & Van Voorhis, W. C. Nature Rev. Drug Discov. 14, 424–442 (2015).

    Article  CAS  Google Scholar 

  7. Pham, J. S. et al. Int. J. Parasitol. Drugs Drug Res. 4, 1–13 (2014).

    Article  Google Scholar 

  8. Corey, V. C. et al. Nature Commun. 7, 11901 (2016).

    Article  CAS  ADS  Google Scholar 

  9. Baragaña, B. et al. Nature 522, 315–320 (2015).

    Article  ADS  Google Scholar 

  10. Phillips, M. A. et al. Sci. Transl. Med. 7, 296ra111 (2015).

    Article  Google Scholar 

Download references

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Correspondence to David A. Fidock.

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Fidock, D. Chemical diversity targets malaria. Nature 538, 323–325 (2016). https://doi.org/10.1038/nature19481

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