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A shocking protein complex

Heat-shock proteins have been found to form part of a large protein complex, called the epichaperome, that improves the survival of some cancer cells. This complex might offer a new target for cancer treatment. See Letter p.397

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Figure 1: The epichaperome in cancer cells.


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  1. Rodina, A. et al. Nature 538, 397–401 (2016).

    Article  ADS  CAS  Google Scholar 

  2. Alix-Panabières, C. & Pantel, K. Nature Rev. Cancer 14, 623–631 (2014).

    Article  Google Scholar 

  3. Bartkowiak, K. et al. Cancer Res. 75, 5367–5377 (2015).

    Article  CAS  Google Scholar 

  4. Meunier, L., Usherwood, Y.-K., Chung, K. T. & Hendershot, L. M. Mol. Biol. Cell 13, 4456–4469 (2002).

    Article  CAS  Google Scholar 

  5. Lee, A. S. Nature Rev. Cancer 14, 263–276 (2014).

    Article  ADS  CAS  Google Scholar 

  6. Sweeney, C. & Carraway, K. L. III Oncogene 19, 5568–5573 (2000).

    Article  CAS  Google Scholar 

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Correspondence to Klaus Pantel.

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Bartkowiak, K., Pantel, K. A shocking protein complex. Nature 538, 322–323 (2016).

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