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Acidic shield puts a chink in p53's armour

Underactivity of the transcription factor p53 can lead to tumour development. The discovery that the SET protein binds to and inhibits p53 points to a way to unleash the tumour suppressor's activity. See Letter p.118

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Figure 1: A shield model of p53 regulation.


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  1. Wasylishen, A. R. & Lozano, G. Cold Spring Harb. Perspect. Med. 6, a026211 (2016).

    Article  Google Scholar 

  2. Wang, D. et al. Nature 538, 118–122 (2016).

    CAS  ADS  Article  Google Scholar 

  3. The UniProt Consortium. Nucleic Acids Res. 43, D204–D212 (2015).

  4. Lin, S.-C. & Li, Q. Cell Res. 17, 301–302 (2007).

    CAS  Article  Google Scholar 

  5. Nair, B. C. et al. Cell Death Differ. 21, 1409–1418 (2014).

    CAS  Article  Google Scholar 

  6. Hamard, P. J. et al. Genes Dev. 27, 1868–1885 (2013).

    CAS  Article  Google Scholar 

  7. Simeonova, I. et al. Cell Rep. 3, 2046–2058 (2013).

    CAS  Article  Google Scholar 

  8. Krummel, K. A., Lee, C. J., Toledo, F. & Wahl, G. M. Proc. Natl Acad. Sci. USA 102, 10188–10193 (2005).

    CAS  ADS  Article  Google Scholar 

  9. Christensen, D. J. et al. Blood 118, 4150–4158 (2011).

    CAS  Article  Google Scholar 

  10. Janghorban, M. et al. Proc. Natl Acad. Sci. USA 111, 9157–9162 (2014).

    CAS  ADS  Article  Google Scholar 

  11. Olzscha, H., Sheikh, S. & La Thangue, N. B. Crit. Rev. Oncogen. 20, 1–17 (2015).

    Article  Google Scholar 

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Correspondence to Michelle C. Barton.

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Barton, M. Acidic shield puts a chink in p53's armour. Nature 538, 45–46 (2016).

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