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Cancer

Acidic shield puts a chink in p53's armour

Underactivity of the transcription factor p53 can lead to tumour development. The discovery that the SET protein binds to and inhibits p53 points to a way to unleash the tumour suppressor's activity. See Letter p.118

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Figure 1: A shield model of p53 regulation.

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Correspondence to Michelle C. Barton.

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Barton, M. Acidic shield puts a chink in p53's armour. Nature 538, 45–46 (2016). https://doi.org/10.1038/nature19469

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