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Cancer

Endothelial-cell killing promotes metastasis

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To migrate into the lungs, cancer cells in the bloodstream must cross the lung's endothelial-cell barrier. A study shows that cancer cells can achieve this feat by signalling to induce endothelial-cell death. See Letter p.215

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Figure 1: Tumour cells migrate into tissues by killing cells that block their entry.

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References

  1. 1

    Strilic, B. et al. Nature 536, 215–218 (2016).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Folkman, J. Cancer Res. 46, 467–473 (1986).

    CAS  PubMed  Google Scholar 

  3. 3

    Dvorak, H. F. Cancer J. 21, 237–243 (2015).

    CAS  Article  Google Scholar 

  4. 4

    Ferrara, N. Arterioscler. Thromb. Vasc. Biol. 29, 789–791 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Minn, A. J. et al. Nature 436, 518–524 (2005).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Gupta, G. P. et al. Nature 446, 765–770 (2007).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Pasparakis, M. & Vandenabeele, P. Nature 517, 311–320 (2015).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Schumacher, D., Strilic, B., Sivaraj, K. K., Wettschureck, N. & Offermanns, S. Cancer Cell 24, 130–137 (2013).

    CAS  Article  Google Scholar 

  9. 9

    Ding, B. S. et al. Nature 505, 97–102 (2014).

    ADS  Article  Google Scholar 

  10. 10

    Furlow, P. W. et al. Nature Cell Biol. 17, 943–952 (2015).

    CAS  Article  Google Scholar 

  11. 11

    Headley, M. B. et al. Nature 531, 513–517 (2016).

    ADS  CAS  Article  Google Scholar 

Download references

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Correspondence to Claudio R. Alarcón or Sohail F. Tavazoie.

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Alarcón, C., Tavazoie, S. Endothelial-cell killing promotes metastasis. Nature 536, 154–155 (2016). https://doi.org/10.1038/nature19465

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